Karima KISSA

Head of ‘Emergence of haematopoietic stem cells and cancer’ team

CNRS -UMR5235-LPHI, Université de Montpellier - France

NOUVEAU

 

UN rendez-vous mensuel PaR WEbInaR sur

LE ZEBRAFISH EN RECHERCHE

 

1ère intervention 

vendredi 18 décembre de 11h00 à 12h30

Emergence of haematopoietic stem cells in the zebrafish embryo

Dr Karima Kissa

Head of ‘Emergence of haematopoietic stem cells and cancer’ team
CNRS-UMR5235-LPHI, Université de Montpellier - France

     You and Science, Zeiss, l'université de MontpellierAzelead et Sanofi vous proposent en webinar tout au long de l'année une série de conférences interactives sur le zebrafish. Chaque mois, retrouvez un intervenant réputé sur une thématique donnée.

Pré - inscription individuelle obligatoire​​

PROGRAMME

Emergence of haematopoietic stem cells in the zebrafish embryo

 

Friday 18th december 2020  11h30 to 12h30

By using zebrafish embryos as a model, we have demonstrated that Hematopoietic Stem Cells (HSCs) emerge directly from the aorta floor through a process called the Endothelial Haematopoietic Transition (EHT). More recently, we demonstrated that the mechanical stress exerted by the blood flow on the aorta induces a series of morphogenetic signals resulting in the activation of HSC specifying genes and the down-regulation of endothelial vascular identity. This gene expression remodelling is thought to drive the EHT leading to the emergence of HSCs.
Our transdisciplinary study capitalizes on the use of specific assets such as zebrafish transgenic model in conjunction with our in-depth knowledge of 4D microscopy, 3D-image modelling, physics and mathematics.

 

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